Calcitonin receptors in GtoPdb v.2023.1

This receptor family comprises a group of receptors for the calcitonin/CGRP peptides. The calcitonin (CT), amylin (AMY), gene-related peptide (CGRP) and adrenomedullin (AM) (nomenclature as agreed by NC-IUPHAR Subcommittee on CGRP, AM, AMY, CT [131, 74, 71]) are generated genes CALCR (which codes receptor, CTR) CALCRL receptor-like CLR, previously known CRLR). Their function pharmacology altered in presence RAMPs (receptor activity-modifying proteins), which single TM domain proteins ca. 150 amino acids, identified three members; RAMP1, RAMP2 RAMP3. There splice variants CTR; these turn produce AMY [131], some can be potently activated CGRP. endogenous agonists peptides calcitonin, α-CGRP (formerly CGRP-I), β-CGRP CGRP-II), (occasionally called islet-amyloid polypeptide, diabetes-associated polypeptide), 2/intermedin. species differences sequences, particularly CTs. CTR-stimulating (CRSP) is another member with selectivity CTR but it not expressed humans [93]. CLR (calcitonin receptor) itself binds no ligand, gives several approved drugs that target this family, such pramlintide, erenumab, "gepant" class CGRP antagonists. also agonist pharmacology; example, displays potent activity at multiple rat mouse [58, 15]. summary table only reflects human pharmacology.